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	Provedor de dados BJMBR (2) Autor Ballejo,G. (2) Martins,S.R. (1) Resende,A.C. (1) Salgado,M.C.O. (1) de Oliveira,R.B. (1) Palavra-chave Nitric oxide (2) Bradykinin (1) CCK (1) CCK receptor subtype 1 (1) Cytochrome P450 (1) Endothelium-dependent vasodilation (1) Myenteric neurons (1) Potassium channels (1) Prostaglandin (1) Proximal duodenum (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2006 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Activation of neural cholecystokinin-1 receptors induces relaxation of the isolated rat duodenum which is reduced by nitric oxide synthase inhibitors BJMBR Martins,S.R.; de Oliveira,R.B.; Ballejo,G.. Cholecystokinin (CCK) influences gastrointestinal motility, by acting on central and peripheral receptors. The aim of the present study was to determine whether CCK has any effect on isolated duodenum longitudinal muscle activity and to characterize the mechanisms involved. Isolated segments of the rat proximal duodenum were mounted for the recording of isometric contractions of longitudinal muscle in the presence of atropine and guanethidine. CCK-8S (EC50: 39; 95% CI: 4.1-152 nM) and cerulein (EC50: 58; 95% CI: 18-281 nM) induced a concentration-dependent and tetrodotoxin-sensitive relaxation. Nomeganitro-L-arginine (L-NOARG) reduced CCK-8S- and cerulein-induced relaxation (IC50: 5.2; 95% CI: 2.5-18 µM) in a concentration-dependent manner. The magnitude... Tipo: Info:eu-repo/semantics/article Palavras-chave: CCK; CCK receptor subtype 1; Proximal duodenum; Myenteric neurons; Nitric oxide. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200014 Role of non-nitric oxide non-prostaglandin endothelium-derived relaxing factor(s) in bradykinin vasodilation BJMBR Resende,A.C.; Ballejo,G.; Salgado,M.C.O.. The most conspicuous effect of bradykinin following its administration into the systemic circulation is a transient hypotension due to vasodilation. In the present study most of the available evidence regarding the mechanisms involved in bradykinin-induced arterial vasodilation is reviewed. It has become firmly established that in most species vasodilation in response to bradykinin is mediated by the release of endothelial relaxing factors following the activation of B2-receptors. Although in some cases the action of bradykinin is entirely mediated by the endothelial release of nitric oxide (NO) and/or prostacyclin (PGI2), a large amount of evidence has been accumulated during the last 10 years indicating that a non-NO/PGI2 factor accounts for... Tipo: Info:eu-repo/semantics/article Palavras-chave: Prostaglandin; Bradykinin; Nitric oxide; Cytochrome P450; Potassium channels; Endothelium-dependent vasodilation. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900017 Registros recuperados: 2 Primeira ... 1 ... Última

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